According to research, several synthetic and natural peptides may promote the release of growth hormones and keep levels stable in the body. Studies suggest that Pralmorelin, or GHRP-2, may be one example of such a synthetic peptide.
Experts believe growth hormones are essential for maintaining a healthy metabolic rate and a wide variety of other biological processes, including those of the cardiovascular system, the brain, and lipid metabolism.
What is GHRP-2 Peptide?
GHRP-2 was created in a lab [i] like the natural peptide ghrelin. First extracted from the stomach, the naturally occurring peptide ghrelin is made of 28 amino acids and may control hunger, growth hormone production, and tissue repair [vi].
Professionals suggest that growth hormones (HGH) may be secreted and maintained at optimal levels with the aid of growth hormone-releasing peptide GHRP 2, as the name implies.
How Does GHRP-2 Peptide Work?
Researchers working with bovines have hypothesized the following mechanisms by which GHRP-2 peptide may achieve its action [ii]:
- It may promote growth hormone (GH) production by acting on pituitary cells.
- It may be a potential GRF (growth hormone release factor) receptor ligand.
- It may activate calcium channels and increase calcium secretion and GH production in response to calcium overload.
- It may increase GH secretion via activating the cAMP pathway and protein kinase C.
Research suggests that adenylate cyclase activity may be increased when GHRP-2 is administered in controlled lab settings. Studies speculate that protein kinase may be activated, and cAMP may be produced. Increased calcium influx and growth hormone release may result from these heightened cAMP and protein kinase levels, as suggested by these investigations. [iii]
Possible Properties of GHRP-2
Researchers suggest that the potential of GHRP-2 may be the same as those of other peptides that might stimulate growth hormone production. Some properties of GHRP-2 peptide, as speculated by clinical trials, could be:
- Potentially elevated levels of growth hormone
- Potentially increased muscle density
- Potentially increased adaptability
- Potentially improved joint health
- Potentially restful sleep
- Potentially anti-aging properties
- Potentially enhanced physical capacity and stamina
Researchers speculate that increases in growth hormone and insulin-like growth factor-1 (IGF-1) may be the end consequence of GHRP-2 presentation. As mentioned above, the properties of the peptide are not limited to those already mentioned; studies suggest that increased levels of IGF-1 may also speed up muscular tissue development and reduce body fat.
GHRP-2 Peptide Research Studies
GHRP-2: General Pharmacological Potential
Animals have been used in several investigations [iv] looking into the pharmacological effects of GHRP-2 peptide.
These investigations have suggested that rabbits and guinea pigs revealed no obvious changes to their central nervous systems after receiving the GHRP-2 peptide. Other than a minor increase in the motility of the isolated rabbit ileum and an increase in the contraction of the isolated guinea pig ileum, GHRP-2 had no other meaningful impact. After receiving the peptide, there were no changes to the respiratory, digestive, renal, or circulatory systems.
GHRP-2 Hormonal Response
This research [v] aimed to learn how the synthetic GHRPs GHRP-2 and Hexarelin (HEX) may affect the levels of growth hormones, prolactin, adrenocorticotropic hormone (ACTH), and cortisol in male test subjects.
The study had twelve research models: six young test subjects and six older research models. The young subjects were presented GHRP-2 and HEX in significant quantities, whereas the older test subjects received less. Research models given GHRH (growth hormone-releasing hormone) were subsequently used as a comparison group.
Research suggests the larger quantity of GHRP-2 may have produced greater increases in GH levels in younger research models than did the smaller quantities on the older test subjects. Its outcome mirrored that of HEX- subjects. Results speculated the GH levels of the GHRP-2 and HEX- models were greater than those of the GHRH- models.
Similarly, GHRP-2 and HEX allegedly increased GH levels in older test subjects compared to GHRH. However, these increases were less than in young adult research models.
The same research suggested that the other ACTH and cortisol hormones also responded similarly to all presentations of HEX and GHRP-2. Although it appeared to elevate prolactin levels, they weren't as high as those with certain other stimulants.
Only academic and scientific institutions are permitted to use GHRP-2. If you are a researcher interested in purchasing GHRP peptides for your clinical studies, you can do so by visiting Core Peptides. Please note that none of the items listed are approved for human or animal consumption. Laboratory research chemicals are only for in-vitro and in-lab use. Any kind of physical introduction is illegal. Only authorized academics and working professionals may make purchases. The content of this article is intended only for instructional purposes.
References
[i] Garcia JM, Merriam GR, Kargi AY. Growth Hormone in Aging. [Updated 2019 Oct 7]. In: Feingold KR, Anawalt B, Boyce A, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com https://www.ncbi.nlm.nih.gov/books/NBK279163/
[ii] Roh SG, He ML, Matsunaga N, Hidaka S, Hidari H. Mechanisms of action of growth hormone-releasing peptide-2 in bovine pituitary cells. J Anim Sci. 1997 Oct;75(10):2744-8. doi: 10.2527/1997.75102744x. PMID: 9331879. https://pubmed.ncbi.nlm.nih.gov/9331879/
[iii] Asad Rahim, Stephen M. Shalet, in Growth Hormone Secretagogues, 1999. Does desensitization to growth hormone secretagogues occur? https://www.sciencedirect.com/topics/medicine-and-dentistry/pralmorelin
[iv] Furuta S, Shimada O, Doi N, Ukai K, Nakagawa T, Watanabe J, Imaizumi M. General pharmacology of KP-102 (GHRP-2), a potent growth hormone-releasing peptide. Arzneimittelforschung. 2004;54(12):868-80. doi: 10.1055/s-0031-1297042. PMID: 15646371. https://pubmed.ncbi.nlm.nih.gov/15646371/
[v] Emanuela Arvat, Lidia Di Vito, Barbara Maccagno, Fabio Broglio, Muni F Boghen, Romano Deghenghi, Franco Camanni, Ezio Ghigo, Effects of GHRP-2 and Hexarelin, Two Synthetic GH-Releasing Peptides, on GH, Prolactin, ACTH and Cortisol Levels in Man. Comparison with the Effects of GHRH, TRH and hCRH, Peptides, Volume 18, Issue 6, 1997, Pages 885-891, ISSN 0196-9781, https://doi.org/10.1016/S0196-9781(97)00016-8
[vi] GHRP 2, GPA 748, Growth Hormone-Releasing Peptide 2, KP-102 D, KP-102 LN, KP-102D, KP-102 LN. https://link.springer.com/article/10.2165/00126839-200405040-00011#
